The rosacea workup.
A clinical investigation guide for adults with persistent flushing, papulopustular rosacea, or telangiectasia — and a dermatology workup that hasn't moved the needle. Four pathways by which H. pylori has been associated with rosacea expression.
A workup for the rosacea that keeps flaring.
This guide is written for the patient whose rosacea has outlived two rounds of topical metronidazole and a course of doxycycline. It maps four pathways by which an unsuspected H. pylori infection has been associated with rosacea expression — and what to ask for next.
It is not a treatment protocol. It is the diagnostic conversation, written down, so the next appointment is more specific than the last.
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i.
The clinical signature of H. pylori-associated rosaceaHow the pattern differs from ocular, granulomatous, and demodex-driven rosacea.
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ii.
Four pathways the dermatology workup rarely tests forVasoactive peptides, cytokine cascade, cross-reactive immunity, gut–skin axis — with the evidence tier for each.
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iii.
Why topical alone often plateausThe systemic question the dermatology room rarely opens — and the labs that open it.
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iv.
Labs to request beyond a topical regimenH. pylori serology, CagA status, hs-CRP, ferritin, vitamin D — read together.
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v.
Testing options for H. pyloriStool antigen, urea breath test, biopsy — trade-offs, costs, and what each rules in or out.
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vi.
What positivity changesEradication, telangiectasia re-imaging, flare-pattern re-scoring — what to expect at 12 weeks and 6 months.
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vii.
A conversation script for the next appointmentThree questions, phrased clinically, that route the workup toward the gastric pathway without overstating the case.
How an unsuspected infection shows up on the skin.
Rosacea in the presence of H. pylori rarely runs through a single pathway. The guide treats each as testable, with the evidence tier explicit.
Vasoactive peptides
H. pylori-induced gastric histamine and nitric oxide signalling propagate systemically and contribute to dermal vasodilation and flushing.
Cytokine cascade
Sustained gastric immune activity drives cytokine elevations — TNF-α, IL-8 — measurable in cutaneous expression and implicated in rosacea phenotype.
Cross-reactive immunity
Anti-CagA antibody titres are elevated in H. pylori-positive rosacea subjects and correlate with telangiectasia severity scoring.
Gut–skin axis
Microbiome shifts and systemic inflammatory load from chronic gastric infection are documented variables in dermal inflammatory expression.
Sharper questions. Better appointments.
The guide doesn't replace a clinician. It gives you the language, the labs, and the literature — so the visit is a clinical conversation, not a search.
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Recognise the clinical signature of H. pylori-associated rosacea and how it differs from ocular, granulomatous, and demodex-driven patterns.
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Name the four pathways — vasoactive peptides, cytokine cascade, cross-reactive immunity, gut–skin axis — by which H. pylori has been associated with rosacea expression.
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Request the right secondary labs — H. pylori serology, CagA status, hs-CRP, ferritin, vitamin D — and read them in combination, not in isolation.
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Decide between testing options — stool antigen, urea breath test, biopsy — based on cost, accuracy, and your specific clinical context.
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Bring a structured conversation to your physician — three concrete questions that route the workup toward the gastric pathway without overstating the case.
Three tiers. One rubric. No exceptions.
Every claim in this guide is tagged with one of three evidence tiers. The summary below previews the four claims central to the case for investigating H. pylori in persistent rosacea. The full reference list — thirteen citations — sits at the back of the PDF.
Rosacea · evidence summary
A few honest questions.
Is this medical advice?
No. It is an investigation guide — written to inform the conversation with a clinician. Diagnosis and treatment decisions belong to your physician.
Do I need to buy the testing kit?
No. The guide is content, sold separately from any Welyon product. It covers all three standard testing options — stool antigen, urea breath test, biopsy — and tells you what each costs and how to ask for it through your existing physician or insurer.
What if my labs are 'in range'?
The guide spends a section on this exact situation — what 'in range' obscures, what to look at in combination, and the secondary markers that frequently shift the picture without changing the headline numbers.
Refund policy?
14 days, no questions. If the guide isn't useful, the Lemon Squeezy receipt has a one-click refund link. We track this to keep the guides accountable.
Who wrote it?
The investigation series is authored by Welyon's editorial team and is being reviewed by the scientific advisory board currently in formation. Reviewer names will appear in the front matter of each guide upon confirmation.
Treat the redness as a question. Investigate the cause.
34 pages, thirteen citations, four pathways, one clear path to a sharper appointment. PDF, instant download.
FDA disclaimer · Commercial interest
These statements have not been evaluated by the Food and Drug Administration. This guide is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before acting on any information presented here.
Commercial interest disclosure. Welyon produces an at-home H. pylori testing kit and a physician-supervised Foundation Protocol referenced in this guide. The presence of these products is disclosed throughout — including on this page, the guide cover, and in the front matter of the PDF — and does not change the content of the guide. The investigation steps described would apply equally if neither product existed.
Editorial independence. Evidence grading in this guide follows the same three-tier rubric used across the H. Pylori Investigation Series, applied identically regardless of whether the resulting investigation routes a reader toward — or away from — Welyon's products.